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Gene ‘switch’ reverses cancer in common childhood leukaemia model

Melbourne researchers have shown a type of leukaemia can be successfully ‘reversed’ by coaxing the cancer cells back into normal development.
The discovery was made using a model of B-progenitor acute lymphoblastic leukaemia (B-ALL), the most common cancer affecting children.
Researchers from the Walter and Eliza Hall Institute showed that switching off a gene called Pax5 could cause cancer in a model of B-ALL, while restoring its function could ‘cure’ the disease.

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